She made her acting debut in the 2002 Telugu film Nee Thodu Kaavali, in which she acted as a housewife at a mere age of 15. This film was a flop, but helped Charmme in getting noticed by the south Indian film industry. Her next film was Kadhal Azhavatillai with Silambarasan, which was also a flop. During this time she acted in a Malayalam film directed by Vinayan named Kattuchembakam. This film also bombed in box office. After that she acted in a couple more Tamil films but they bombed at the box office.Her re-entry to Telugu movies happened with a film with Sreekanth which was a failure; then in Sri Anjaneyam, directed by ace director Krishna Vamsi which too was a failed attempt. It was followed by another failure with Chanti, paired against Ravi Teja. She finally got a big break in Telugu with Gowri in which she was paired with Sumanth. She didn't have to look back afterwards. The stupendous success of Mass with Nagarjuna strengthened her position in Tollywood. Charmme's most indistinguishable and critically acclaimed film so far is Anukokunda Oka Roju. It was a heroine-oriented thriller. Her performance in the movie was acclaimed by critics.In 2006 she acted in Pournami which was a total failure in spite of high expectations, but her performance was appreciated. Though she did not learn Indian classical dance, her Bharatanatyam and Kuchipudi dances in the film were appreciated by audiences. Later that year she was paired for the second time with Sumanth in Chinnodu but it was not a successful venture. Her next film, Rakhi (with NTR), was a hit. In 2007 Mantra, a thriller with Charmme in the lead role, was declared as a surprise hit.This performance fetched her the Nandi Award for the best herione of 2007. Her performance in the movie is appreciated by wide range of audience.Then, she starred in several lady oriented roles, a rare thing in Tollywood. The list includes Anukokunda Oka Roju, Mantra, Manorama 2009, Kavya's Diary in Telugu and Laadam in Tamil, out of which Anukokunda Oka Roju and Mantra were very successful.